【Overview】 COS Strategy Engine v7.6.1 (SAFE) is a browser-based self-learning web calculator designed to support individualized controlled ovarian stimulation (COS) planning. No installation required. Runs offline entirely within your browser. Data never leaves your device. Key functions: • Gonadotropin starting dose calculator (based on age, AMH, target oocytes) • MII retrieval predictor (with FmOI-based trigger decision) • Baseline vs Extension scenarios • Interactive heatmap (Days × Follicles) • CSV/Excel self-learning: refit regression or Poisson models using your own data Included files: • COS_Strategy_Engine_v7_6_1_SAFE.html (main app) ・COS_Strategy_Engine_User_Manual_JP ・COS_Strategy_Engine_User_Manual_EN • ReadMe_ja_en.txt • License_Kobanawa.txt • Reference papers • Developer signature (Signature.txt) References 1. Kobanawa M, *The gonadotropins starting dose calculator: A model-based approach to individualized ovarian stimulation.* Reprod Med Biol. 2022;21:e12499. 2. Kobanawa M, *Predicting the optimal timing for triggering in controlled ovarian stimulation: Mature oocytes retrieval predictor.* Reprod Biol Endocrinol. 2025;23:1489–7. License: Personal use only (single license per user). Redistribution, resale, or modification is strictly prohibited. Developed by Masato Kobanawa, MD Kobanawa Clinic, Japan